my DH started on 150mg of SR last week, then 4 days later jumped up to 300. That caused major anxiety and agitation so he went back down to 150mg 2 days later. He's also taking 300mg of Effexor.

He is exhibiting a return of major depression symptoms. has anyone else experienced this? Should we just discontinue or will it pass? We've been told that the combination of Effexor and Wellbutrin is very effective. He's been severely depressed since October and no remission yet.
Will be talking to Pdoc today, but really appreciate the input from this board (always very truthful).

Anything you can share is greatly appreciated.