Anxiety and agitation are common side effects of Wellbutrin, although I agree that your DH probably escalated a bit quickly.

I've been taking Wellbutrin for a number of years, and in the early going a small amount of valium was very effective in alleviating the anxiety, and remained that way for quite some time. I've deteriorated some since then, so I am on a more potent med for the anxiety and agitation ... but that anxiety and agitation does not appear to be drug-related from Wellbutrin.

Just FYI, it's your doc's call. The Effexor may have some kind of drug-drug interaction with Wellbutrin as well.