I've been on wellbutrin xl the longest. It has never given me problems.

I started on viibryd last December. It is expensive and insurance tried to deny coverage for it, but they eventually approved it. It has worked beautifully for me. I take it with the wellbutrin xl. Pdoc has found I do best on a combination of antidepressants.

Effexor xr really worked well for me until it just stopped working (a common problem for me). Many people have a hard time withdrawing from it though. I was able to get off of it fairly easy with a few side effects, but nothing too hard to work through.