I do well with Cymbalta; I have been on every SSRI and none helped. The SNRI made the difference. Not only that, but between Effexor and Cymbalta, Cymbalta I choose because it lets me still orgasm. The SSRI's and the Effexor--I could not orgasm and I will not tolerate this. To me, that ruins my quality of life. So, I am not thrillingly happy, by any means, but Cymbalta helps me function while still allowing me to both cry and orgasm. Hope this info is helpful.