I've been on Cymbalta for over ten yrs, went from 60 to 90 mg/day about a yr ago with only desired effects. I'm also on Topamax as a mood stabilizer. I have to be aware of the propensity to tip into mania, but otherwise there are no negatives. Nothing else worked, largely because of side effects that far exceeded what I could tolerate.
Hope you fare well with it!