I can't say much in regards to the anti-depressants as I have no experience taking them vs not taking them.

However I feel like I've been in a similar relationship situation. I broke up with my ex last February because I didn't feel happy. I felt like I was always irritated with him, I wasn't physically attracted to him etc. Well as soon as I broke up with him I felt like I made the biggest mistake and called him up and told him I was wrong and wanted to be with him and we got back together.

Didn't take long for my previous unhappy feelings to return. We ended up breaking up a few months after the first break up, and again it was hard but we stuck it out and it ended up being the best thing.

I'm not saying that will be the case for you (ending things for good) but give it time. It will hurt at first whether its the right decision or the wrong decision, but only time will tell whether its the best decision for you.

I wish you all the best- hang in there