Probably not. I think the half life on abilify is longer than 48 hours and I know it is for zoloft. Synthroid and lithium take a long period of time (over weeks) to build a therapuetic level in your system.

However, if you are not consistent on the weekends it may lead to missing even more days by getting out of your routine which could lead to dosing problems. Just give your liver a break take your meds and slow down on the booze.

Infact, it is more likely to be the alcohol that is making your moods more unstable. It is a known fact that alcohol is a no no for people with bipolar. My pdoc doesn't even want me to use mouth wash to rinse my mouth unless it is free of alcohol. That is how sensitive she thinks it is. Also it only takes 4 oz of liquor to reach that relaxed, intoxicated state but people do not understand that and drink way beyond what is required for social relaxation. Hard to do, I know......