It doesn't matter how the weight came into existence, the metabolic syndrome is a direct result of the stored fat.

It has only recently been recognized that adipocytes, the fat storage cells that get so plump, are actually glands. They are dormant glands when they are empty of fat. But they're all plumped up, they start secreting modulatory chemicals.

When people get liposuction, they're actually getting adipocytectomies. All those little fatty glands are being sucked away. And the effect can be dramatic, because the hormones concentrations are almost instantly normalized again.

I am not advocating liposuction. I am simply contextualizing adipocyte biology.

When you start losing weight, adipocytes notice the shift in fat balance. They're secreting more fat than they're taking up. And they fight hard, but only for so long. Then they go back to being dormant glands again.

Back to metabolic syndrome. As I said, it doesn't matter how you got heavier with fat. The chronic effect of all that glandular mass is what leads to disturbances in sugar metabolism. Prediabetic state is nothing more than the wobble that comes before the crash. Your blood chemistry is clinically disturbed.

If you can lose weight at a pound or two per week, you can get those adipocytes back into balance, with the least adverse consequences.

Lar