I had a similar experience with feeling just fine for many years, then depression came on like a storm...I tried to fight it without medication for about a year; then, I was visited my primary MD, told him what I was feeling, and he prescribed lexapro. It worked like a champ (other than the massive weight gain). I went off the medication with his advice. After being off the medication for about 4 months, I found out that my wife was having an internet affair...that I was able to handle for a little while, but then my depression came back. I tried lexapro again, but only experienced side-effects. So, off of lexapro, then on to bupropion xl...then, the tinnitus started and it was about to push me over the edge. I'm off of meds for about 3 full days now. I have a follow up with the MD in early July. Before that, I'm going to see a clinical psychologist for at least one session...never give up, and never fail to consider any and all options, whether it's talk therapy or pharmacotherapy or a combination of both. There is hope.