Depends on what you have - I have bipolar I disorder, but we very carefully titrated the meds along with my regular meds - Paxil and Zyprexa. So far, no ill effects, no mania, no "crash" into depression after the concerta wears off and I can sleep just fine. As far as I'm concerned, it's a godsend. Sort of like mania but without the psychosis or the irritability or the dumb shopping.

Hope this helps!

some of it's magic
some of it's tragic
but i had a good life all the way......
~jimmy buffett