You may adjust to it given some time. My husband has taken it for a long time. It knocks him out very quickly at night and generally he's okay during the day. He has to get up for work about 4AM, so he takes the seroquel around 8PM so he can function in the morning. I believe he is on 400mg, maybe 500mg. I've lost track.

I've taken seroquel for short periods of time for sleep, but I wasn't very fond of it because I really feared feeling drugged. I can't remember if that was actually a problem though. My pdoc switched me over to seroquel xr which was better. The extended released eases into function instead of hitting you like a brick as the regular version does. I definitely preferred it, but I didn't stay on it terribly long. Again, it was mostly for sleep and once that issue was in hand, I discontinued the seroquel xr.