I am on deplin now with little effect. Maybe a slight boost to my lexapro? Anyway my psych said that 30% of white folks have the folic acid issue that deplin solves, so its kind of more likely to not work than it is to work. Worth a try though, if you are white 30% is a lot of us . I read the pamphlet for it at his office and he also told me their pamphlet REALLY stretches the effectiveness lol. Give it a shot though, it really has 0 consequence if it doesn't work if you can get free trials like I did.