I have been on Prozac for nearly three years now. I haven't gone manic on it, but I have also been on other meds on and off that would put me into a mixewd episode or a hypo/manic episode. Wellbutrin caused too much anxiety at a therapeutic dose so I had to go off of it. Otherwise, a low (150) dose did nothing.

Right now a combo of Prozac, 40mg, Depakote, 500mg, Neurontin, 1800mg, Geodon, 60mg, Trazodone, 100mg, Prilosec (for the heartburn that Depakote causes) propanolol, 20mg, Levothyroxine, (I forget the dose) and twice a week ECT is helping. I would love to get off some of the meds so I can lose the 70 lbs I put on since starting meds.