I've been on Lamictal for about 2 years now, this time. I've been on it twice before in the past, but didn't give it a sufficient amount of time to get to the right therapeutic dose. Currently I take 400 mg, and it seems to work pretty well. Keeps me from going manic. Helps with the depression a little, but had to add Tegretol to the mix recently to help with the depression, which actually worked.