I've been on lamotrigine since November. It took a while for it to take effect (I'm at 300mg now), but once it finally did, it's kept me almost rock-hard stable. I do still have a low-level depression sometime, but it's not disrupting my ability to function anymore. My high moods don't get out of control either.

I do have some side effects, but they're tolerable. Dry mouth, especially overnight and into the morning, though I can pretty much expect that with any psych med. I also get a mild but tolerable itchiness all over my body, though no rashes. I get a touch of restlessness and insomnia, and my short-term memory is pretty much shot at this point, though I'm sure a big part of that is just the bipolar. I'm also having a hard time focusing on one thing at a time - I jump from task to task, it's eerily like ADHD, methinks. Oh yeah, and I yawn like crazy.

I do notice if I miss a dose, especially in the morning (I take 200 when I wake up, and 100 before bed) I slip into a foggy-headed depression for the rest of the day, and taking it in the middle of the day doesn't help much though once I take my dose the next day, I am fine.

I'm considering asking my pdoc about augmenting the lamotrigine with an antidepressant - I'm thinking wellbutrin perhaps. Overall though, I wouldn't drop my lamotrigine for the world, I've gone from deep suicidal depressions and a horrible mixed episode, to nearly stable, and always functional.