I was on zoloft/setraline for 3 years before it pooped out. The start up was easy for me, and I even (stupidly) cold turkey quit twice with little trouble. The 3rd time I came off of it it revealed my major depression/anxiety to be worse than ever, but this was just a timing coincidence. Overall I enjoyed my experience with the drug. Mild dizziness was all I ever had and it was rare. Zoloft is not a week 1 med in my experience. I took 3-5 weeks before it even STARTED to help, but when it did it was a quick fix. Good luck with it and remember setraline is one of the more "safe and mild" meds in the Antidepressant world.