cannibis reacts to my meds by causing blackouts when i use it.. Probly the same for you. And the prozac i would not know cause i never drank when i was on prozac, (no access). I would not drink and smoke if i were you if thats how the two affect you on ur meds. I know easy said than done but the way it sounds it could be dangerous since when your blacked out you dont know what your doing, and where your going, you could end up waking up on a curb robbed and mugged in some city and not know where you are. Black outs are dangerous and scary. Is it worth it?