Sometimes when I want to be knocked out because I can't stand lying awake in bed, hoping that the Seroquel will make me drowsy enough to fall asleep. I chug a 1/2 cup of vodka mixed with juice or pop and take my meds. I'm able to fall asleep within the hour doing that. I only do it when conditions are extreme and I'm worried about what I'll do if I'm still puttering around awake.