I have been put on Prozac, Paxil, & Zoloft in the past (by several different GPs and PDocs). Abilify was added to combat the mania. The only thing Abilify did was give me rather severe akathisia. That was not fun. My current Pdoc took me off of Zoloft rather quickly when I started to tip into mania. In his opinion, Bipolar Disorder patients don't mix very well with ADs.