I take Zoloft and have had no problems with it causing mania. I also take Invega with my zoloft it seems to be a great combo for me. I would talk to your doctor and see what they think of this combo or another combo of meds for you. I have been on the Invega for 6 years now and have never had any side effects from it. The zoloft though I have only be on for a few months but it works well for me. I was on prozac before and it stopped working for me after 6 years of being on it. That's why I am now on the zoloft. Good luck hope they figure something out for you.