I have gained, between my psych meds and my hypothyroid, quite a lot of weight. I went from 148 to 215 in the space of two years. I am at the 215 now. I have been posting with a site called Transformation.com. There is also a book by the same name. The guidelines are really healthy, the workouts intense. I haven't seen any movement on the scale, but I am feeling so much better by following the plan. I even have more confidence. I hold the belief that at some point the scale will budge.
There are even a few bipolar folks posting over there.