Hi! This is my first reply to anyone on PC so I hope I'm not over stepping. Not knowing any details of course, just from my own person experience - I don't know what deplin is; but my experience with zoloft was that the higher the dose it made me very tired (not zomby-like but didn't help w/ depression) and perhaps it DID help take the edge off my anxiety it never really touched my depression. I was recently in the hospital (my choice) and a great pdoc switched me to Effexor XR - and at a very high dose. It made a world of difference with anxiety and once I got up to 225mg also helped with my resistant depression. Just wanted to put that out there for you. I asked my pdoc about effexor after reading about it on www.crazymeds.com - said it was best for resistant depression and anxiety. hope this was informative!!
- take care 'a you!

cate