If you operate machinery and will be taking meds that make you sleepy, or kind of out of it then maybe a little time off to adjust might be a wise thing to do. The meds all hit us differently, for me they usually hit quite hard the first few days sometimes much longer depending on what I am taking.

It would be awful to have an accident at work where you or others could get injured. Could you still take the leave but if the adjustment goes well, go back to work sooner than planned?

I am on disability so I havent had to take time off either. But I think that's what I would do.