How many meds did you have to try before it worked? I have been trying to get out of my most recent depression with meds for 2 months now and it's not working at all. I tried Celexa, now Cymbalta and am up to 120mg and I'm still totally depressed, no energy at all, can't get anything done but maybe take a shower. I've tried cymbalta with and without abilify this time too. Four years ago I had my first deppression and tried zoloft, didnt work and then a couple others when in the hospital because it got so bad and NOTHING could put me to sleep and lexapro finally helped but it might have led to a severe manic episode. I tried lexapro again during another depression two years ago but it didn't help this time - this is soooo hard!