I have definitely changed since being diagnosed. Little things that you don't think about until someone brings it up to you. I do know that when I was taking just Geodon, 80mg twice a day, it really affected my personality. I didn't notice it, but my husband and therapist were saying that I just acted like I didn't have much life in me, no emotions really. But now with the combo I'm on, it looks like it's made me manic. So I think meds make a difference.