Momma is right about the seizures, I just had that happen to me with topomax. I went three days without it and had a siezure. Not good, and then for three days later had tremors. Not a good feeling very scary. I have weined myself off of my meds before and not had the horrible side effects but after about three weeks of being off of them it is always the same thing feeling suicidal, very depressed back on the couch disappearing from the world and my life. I commend those who can go off of meds and there are a handful on PC that I know of who have successfully done so. I think its awesome and I wish I could do it. I guess it just depends on the severity of your bipolar and well the person in general.