little things that add up together to make a puzzle out of pieces of thoughts. like, not able to sleep for 3-4 nights unless have a sleep med at bedtime, lacking motivation to do anything, not caring about one's life, isolating self from other living people, and not able to concentrate as often during the day as before. I get negative thoughts that can swing into periods of "numbness" having no emotional pain. This is despite being on medication. It was worse before I had any antidepressant.