It seems like every medication I've taken has lost its effect after about 2 years. I've been on meds for 12 years, so you can imagine how many different meds I've tried. Right now I'm on wellbutrin and clomipramine. I've been on clomipramine for almost 10 years and it's the only one that has continued to work. I've found an ok combination of the clomipramine and wellbutrin, but it's not as good as it was when I first started taking it. Now I'll probably have to up the dosage. Then once I max out, try to find something else. It's kind of been a nightmare. Meds curb the anxiety and the deeper depressed feelings, but they don't get rid of them completely. For me, it was more like taking the edge off of things. I went to therapy, but that never seemed to help much either. The one good therapist that I had while I was still living in Florida passed away. I credit her with saving my life. After that, I saw a psychiatrist that was a pill pusher, and a therapist who was more concerned about what I thought of my acne then the fact that I was depressed enough to want to hurt myself. The only things that have really kept me here are my close family and friends. Talking to them is better than talking to a therapist for me.