You might not think that chemistry matters, but the evidence suggests otherwise. What drugs specifically do you have in mind that are no more effective thAn placebo? I know I do not take such drugs - why would I? I do not take sugar pills - there is research and proof behind everything that I take.

http://www.medicalnewstoday.com/releases/29365.php - Geodon way more effective than placebo in stopping acute mania or mixed state.