My wife of 35 years has been treated for years for depression. She has attempted suicide early in our marriage, left me several times mid-marriage, divorced me for 9 months and returned, admitted to mental health facility for 2 weeks three years ago (left not following through with therapy), has had 7 jobs in the last 5 years, quitting without notice, she will not even try to mingle or engage people (familiar or unfamiliar), stays up all night and sleeps all day, does zero housework, has now left me accusing me of being the cause of all her problems. She is totally non-confrontational. My problem is: she now seems manipulative, uncaring, irrepsonsible, vagarious, and arbitrary. She claims we have come to the end of our line together, with the added kicker of "no turning back". How do I know if she is irretrievable? I will never forgive myself if I don't give it every effort, yet at 63 with leukemia, I cherish each day and feel as though I am being robbed.