My 19 yr.old daughter just recently had this problem with her friend...they have been best friends for the last 2 years...but her friend starting drinking and doing other things that my daughter is not into...their goals in life are totally different...my daughter tried avoiding her friend, but that just made her friend even more persistent with phone calls and im's...so my daughter spoke to her and said that she needed a "break" from the friendship..my daughter is away at school and her friend is not..this caused a separation for a short time between them.. they are still friends, though the closest of the relatinship has changed...and my daughter is glad that things have changed...