Yes the dr when I was inpatient said that Zyprexa and lithium work really well together. As the Saphris did a huge number on me and left a hole (and frankly I believe me in the psych hospital) in my meds, they asked if i wanted lamictal or topomax. I said no lamictal I don't want my skin falling off. The German dr said "Oh! Yoof bin reedink!" so yeah . Because of my migraines that I can't use any meds to abort except the ER I chose topomax. My pdoc once said it was a last choice I don't know why. After this Saphris fiasco I'm not playing around and frankly I'm happy with the topamax. More than happy.