W/ my meds if I know in advance we are going to have a weekend alone I skip my meds just one day and delay as long as possible taking them the day of the big event. A day and a half is about all I can go w/ out starting to feel weird from lack of meds. But sexually it is usually enough to get the big "O" and satisify my H and I both with a little extra work. Would that help you I don't know?