I also use Topamax to suppress appetite. It is an overkill - I did not want to suppress appetite to THAT extent. I basically stopped being hedonistic in regards to food. I do not like it. But, Topamax is a finicky med in that if you stop and resume, you would no longer get weight loss from it. You would get migraine prevention still but not weight loss. That makes me reluctant to stop. That said, I think stopping for a day and a half that you are recommending would not count as a full "break".