I've been treated for chronic depression for almost 30 years now and taken almost every med out there. My situation is that when a med plus supplements plus exercise work, suddenly they just stop working for no reason. My cycles last maybe 2-4 months. Four good months are almost heavenly -- it is the closest to being "normal" I ever am. But often, it will be two normal months followed by four months of living hell. And my swings are unpredictable, it used to be always fall/winter were bad, now I never know. Summer can be bad, then winter ok ... fall ok one year, horrible the next. I am a real stumper to all the professionals. Which honestly, to me, means that if I didn't still have one child left at home to raise, I would consider moving away and that way if I ever wanted to drink it would at least be away from my family. (and I'm an alcoholic, so drinking would eventually be death to me.)