I notice a huge change with meds and I would never go without meds- unless I was manic and decided that I wanted to "be the real me" like I did a few months ago. But normally, no. I just started topomax about 3 weeks ago and I've noticed a change for the better so its definitely doing something. When my brain "goes bad" it just goes bad. One only has to read my blog from when I was in the hospital recently to see that I wasn't thinking my normal way. If left to continue down that path without treatment I don't know where I would have ended up.