I have been on Lithium, Zypexa, Depakote, Trivil, Tyridizine, Pameril, Tegretol, meprobamate, phenobarbatol,E.S.T.stellazine, thorizine, My thyroid got messed up on Lithium, on Depakote I gained huge weight had a heart attack. I can't go through weight gain and heart problems anymore because I am too old to keep going through that. I wanted to go back on medicinee for the mania due to social and mental major difficulties that are almost insurmountable and unlivable. So I am willing to take Topamax, I am so in pain with Bp.