I take 900mg a day .. I think it helps. I did blood work a few times when increasing dose.. Last blood work showed me at the low end of "therapeutic range" so I stopped increasing as my Pdoc and I felt it was time to stop fiddling and leave things alone.

Its weight neutral for me. No side effects. You will have to increase your fluid intake unless you are already drinking a couple gallons a day like I do and have done for years.

Hope you find a good Med/ med combo for you