I have been taking medication for eleven years, and have been on a number of antidepressants. The one I am on now is the Buproprin (Wellbutrin) SR 150twice a day. For the past 3 years I was on 100 mg twice a day, but recently had to up it do to the bad weather and some things that have been happening in my life. However, out of all the antidepressants Buproprin has worked the best. I don't want to scare you but I had some very bad side effects for about a month when I first went on it. But I was also going through the Paxil withdrawals the same time they first started me on Buproprin. So I'm not positive how much was the Paxil and how much was the Burproprin. The derealization you were talking about I've had off on through my life, but the side effects of Burproprin seems to intensifies it. I did alot of research when I first went on it to know what exactly was possible as far as sideeffects and that seemed to help me deal with them because I knew the medication was what was causing it. If you are willing to stick it out for a month or so it should help you. It does feel like a little like speed at first, but after that second month I leveled out and no longer felt what is best described as a mania episode. I am not bipolar so this was the first mania I had ever experienced, but it faded. I hope this information is helpful.