You really can't compare doses of one med to doses of another. They just don't really work that way. Each med has its own dose measurements, and just because you take a "larger" dose of one med doesn't mean it is stronger than the other. That's just the way each med is measured out.

Wellbutrin is considered activating, meaning it has a common effect of helping with energy level in many people. In fact, for some people it is too activating (particularly people dealing with bipolar disorder) and can create mania.

I've been on wellbutrin xl and it worked really well for me. I generally take 300mg. I've never had to take it more than once a day. Perhaps regular wellbutrin works differently than the xl version and might require taking it more often as it wouldn't be timed released.

I've taken it in combination with other antidepressants, but not with zoloft. It worked well for me in combination with pristiq and also with viibryd (not all 3 at once). Sometimes a combination of antidepressants works well for people as different antidepressants work on different neuroreceptors (all too technical for me, but your pdoc could explain). I'm one of those people who generally needs a combination of AD's or an AD with a mood stabilizer for greatest effect.