Thread: How Long Should You take an SSRI?
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Old Dec 27, 2012, 01:07 PM
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~JD~ ~JD~ is offline
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Member Since: Dec 2012
Location: Pacific NW
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Quote:
Originally Posted by farmergirl View Post
Actually, they can stop working; there is even a name for it: tachyphylaxis.

http://www.mayoclinic.com/health/ant...ssants/AN01312

http://www.johnshopkinshealthalerts....ty_3288-1.html

http://www.ncbi.nlm.nih.gov/pubmed/18694599

I have had to switch antidepressants several times due to this problem. It's hard to know why it happens, but in a few patients this can be a problem. Generally, switching to a different AD has corrected the problem quite well.
Previous exposure to an SSRI/SNRI increases the initial efficacy and decreases the amount of time it takes the medication to start taking effect on the the serotonin or norepinephrine ruptakes.

Also, your examples include:
1) A single patient on 20mg of Celexa.
2) A single study spanning a total of 83 test subjects
3) A doctor saying that some people may experience a "poop-out effect" (very professional wording) but the entire article explains how it can be attributed to a multitude of other factors.

So I'll stick with my original statement.
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