Hi,
I just took my last dose of seroquel last night. I have been weaning off 300 mg daily for about 6 weeks. I have been on seroquel , various doses, for about 7 yrs.

Seroquel took a great toll on my body physically. I gained about 80 pds. Because of that weight gain I now have extreme high blood pressure.

I have Rapid cycling Bipolar 1. My PDOC put me on Seroquel to control dangerous mixed states. I agree maybe it did help a little with that, but it turned me into a couch dwelling zombie. In my view it did not help that much. I stayed on it because of his strong arm tactics. NOT ANYMORE! NEVER AGAIN!

Before seroquel I was active, creative lover of life. Yes I had bad mood swings but I was able to engage in life.

Seroquel has taken so much from me. Now I start the long battle back from it.
Unfortunatly, I can't take antidepressants they all make me manic and I start to cycle very quickly.

Have you tried Lamictal for bipolar depression ? It doesn't cause mania. I took it and it was working very well until I had a rare allergic reaction to it.

If you have Bipolar disorder, be careful with antidepressants.