My pdoc will always call me back the same day I call with a problem. It may be in the evening by the time he gets a moment to call, but he always calls. He calls in any med changes directly to my pharmacy and then if he wants me to come in sooner than my scheduled appointment, I generally can get in within a few days if I can be flexible with my schedule. He does take appointments until 6PM, so usually it isn't a problem.