I tried 150mg of Wellbutrin. It really lifted the veil of tiredness that I was struggling with... but it made me too grouchy. So I started breaking the tablets in half, for 75mg daily. The grouchiness went away--yet the smaller dose was still very helpful with the fatigue, which surprised me, as I thought 150mg was considered a rather low, starter dose. I plan to ask my doc whether WB is available in a 75mg size. (Disclaimer: Changing a dosage without your doc's advice isn't recommended...)