My diagnosis is bipolar disorder. Recently started with a new pdoc. I had been in a manic state for many weeks. Had been on a high dose antidepressant and no mood stabilizer. New doc cut the dose in half and started me on Saphris for mood stability. Depressive state came crashing in soon after that. After four weeks, felt great (almost too great) but that only lasted about a week and a half. Can't seem to find the middle. Does anyone out there know if this medicine just takes a long time to work or what? Maybe I need the dosage adjusted?