I'm on a medication called "Symbyax", which is simply a combination of Zyprexa, which you''re already on, and Prozac, the most famous SSRI ever. Symbyax is one of two meds approved by the FDA to treat bipolar depression. (The other is Seroquel, which is an atypical antipsychotic with antidepressant qualities.)

The Symbyax has been a miracle drug for me. I'm not depressed, at all. Admittedly, I do run a bit hypomanic most days; the Prozac is probably to blame for that. Maybe if I wasn't on an SSRI, I would be more "stable". One thing I know for sure: between the antidepressant qualities of zyprexa, prozac, and wellbutrin, I have mood swings, but I can deal with them. Without a "destabilizing" SSRI, I would still be having mood swings, and I wouldn't be able to deal with them. That is my opinion regarding the use of antidepressants in the treatment of MY bipolar disorder. take it for what it' s worth.