I take clozaril since 2007 for bipolar. It has worked well for me. If I run out of it for a few days I started having difficulty sleeping and sometimes get a bit manic. As netsavy said it can cause drooling and I have that side effect at night which is annoying.

When you initially start taking it you have to have a CBC every week for six months, then every two weeks for six months, then every month as long as you take it. I have never had a problem with my white cells fortunately.