I was just on this combo for allmost 2 weeks at day 6 the side efects got to the point at the 12 hour mark of taking meds I was psychcotic and terrified,after 4 days of this and told to just give it a chance I thought I had and I quit the wellbutrin150 xl. I have been on zoloft since 2005. It seems this combo works great for most but not all, as I found others in the same boat as me. I hope this combo works for you, I also say give it a chance. You will know how it works for you.