I do not think it is a given/no-brainer and like they have tested a connection. If one has support somewhere and/or is taught stress management techniques as one is growing up, etc. then the chemicals/hormones are not going to change in the same way as if one is not.

Mice are fine to use, not like mother mice are going to teach them ahead of time how to deal with constant swimming over time with no way to rest :-) changing their chemicals/hormones is "easier" to see how it affects their behavior, etc.

We could probably better moderate the release of stress chemicals/hormones and/or check the adrenals in puberty (I have an adrenal incidentaloma I had to see an endocrinologist and he taught me signs to look for if it was causing problems but who knows, I was over 50 when they found it, perhaps it formed/influenced my teen years which influenced my adult years, etc.