I agree with what hamster said. Tho you have to wait until she's done breast feeding, you already know that antidepressants work for your wife. That's great! So make sure she gets back on her meds after she's done breast feeding.

Therapy would be very beneficial also. I don't know if she's ever gone thru therapy but it sure did ME a lot of good. I had issues that went along with depression, and dealing with them too made a world of difference! There are many times issues we don't even know we have. So it's a good idea to go thru therapy. She won't regret it, I'm sure of that. It CAN be painful at first but after we get thru the painful parts, we begin to heal. I'm sure the therapist would want to delve into her childhood. And I'm sure that would be painful for her. But I believe she needs to do that since she won't talk much about her family. Anyone who is THAT sensitive about family needs to see someone.
I wish you the very best. Take care and God bless. Hugs, Lee